In order to be an effective teacher, it is important to prepare students for their future in the 21st century. Students are expected to be able to problem-solve and make connections beyond the silos of single discipline classrooms. The purpose of this literature review was to examine interdisciplinary instruction and how it affects student learning. While researching, multiple themes arose including how interdisciplinary learning improves student engagement as well as efficacy. In addition, studies indicate that interdisciplinary methods help students develop problem-solving and higher-order thinking skills. Last, interdisciplinary learning creates opportunities for students to build relationships with both teachers and classmates and often led to academic success.