This literature review depicts strategies educators can implement to facilitate 21st century learning and innovation skills in classrooms: collaboration, communication, creativity, and critical thinking. One challenge educators currently face with implementing these skills in the classroom is being required to move to online learning or other learning formats as safety and health remain a top priority during the pandemic. This has caused teachers to reinvent the way they teach their students to communicate, work with one another, and display critical thinking and creativity skills. Many educators are reinventing teaching in schools without an increase in resources and guidance from the state or federal levels. This literature review analyzes research- based strategies in successfully implementing the four learning and innovation skills: collaboration, communication, creativity, and critical thinking. The presented information and strategies can be used during and beyond the pandemic for families, educators, and schools to reach this ultimate goal of preparing lifelong learners for success.